News

Kiadis Pharma receives IND approval from FDA to start pivotal clinical trial with ATIR™ 08-07-2010
Biopharmaceutical Company Kiadis Pharma announced today that it has received approval for its Investigational New Drug (IND) application with the US Food and Drug Administration (FDA) to start the pivotal clinical study for its product ATIR™ in the United States. Kiadis Pharma is currently... read more 

Kiadis Pharma Provides ATIR™ Update: Two Year Follow-Up Data Show No Cases of Transplant Related Mortality - FDA grants ATIR™ Orphan Drug Status as a Medicinal Cell Based Therapy to Reduce Transplant Related Mortality 28-04-2010
Kiadis Pharma today provided an update on its cell therapy product ATIR™ developed for mismatched bone marrow transplants. ATIR™ continues to show excellent clinical results in patients who received a mismatched bone marrow transplantation from a family member donor. The two year follow up data... read more 

Publications

Articles

2008

Perruccio; Katia, Fabiana Topini, Antonella Tosti, Alessandra Carotti, Teresa Aloisi, Franco Aversa,Massimo F. Martelli, Andrea Velardi. Photodynamic purging of alloreactive T cells for adoptive immunotherapy after haploidentical stem cell transplantation. Blood Cells Mol Dis. (40):76-83, 2008.

 

2007

Mielke; Stephan, Raquel Nunes, Katayoun Rezvani, Vicki S. Fellowes, Annie Venne, Scott R. Solomon, Young Fan, Christian Scotto, Elizabeth J. Read and John Barrett. A clinical scale selective allodepletion approach for the treatment of HLA-mismatched and matched donor-recipient pairs using expanded T lymphocytes as antigen-presenting cells and a TH9402-based photodepletion technique. Blood Prepublished online Sep 24, 2007.

 

2005 

Sidi Boumedine; R. and D.C. Roy. Elimination of alloreactive T cells using photodynamic therapy. Cytotherapy 7(2):134-143, 2005.

 

Mielke; Stephan, S.R. Solomon and A.J. Barrett, Selective depletion strategies in allogeneic stem cell transplantation.  Cytotherapy 7, (2) 109-115, 2005

 

2002

Guimond; Martin, Antonia Balassy, Melanie Barrette, Sylvie Brochu, Claude Perreault, and Denis Claude Roy. P-glycoprotein targeting: a unique strategy to selectively eliminate immunoreactive T cells.  Blood 100(2):375-382, 2002.

 

Chen; Benny J., Xiuyu Cui, Congxiao Liu, and Nelson J. Chao. Prevention of graft-versus-host disease while preserving graft-versus-leukemia effect after selective depletion of host-reactive T cells by photodynamic cell purging process. Blood 99(9):3083-3088, 2002.

 

Anasetti; Claudio. Photodynamic purging of immunoreactive T cells: the magic bullet? Blood 99(9):3081, 2002.

 

1999

Villeneuve; Luc. Ex vivo photodynamic purging in chronic myelogenous leukaemia and other neoplasias with rhodamine derivatives. Biotechnol. Appl. Biochem. 30:1–17, 1999.

 

1996

Pal: P, Zeng H, Durocher G, Girard D, Li T, Gupta AK, Giasson R, Blanchard L, Gaboury L, Balassy A, Turmel C, Laperrière A, Villeneuve L. Phototoxicity of some bromine-substituted rhodamine dyes: synthesis, photophysical properties and application as photosensitizers. Photochem Photobiol. 63(2):161-8, 1996.

 

Villeneuve; Luc , Prabir Pal, Gilles Durocher, David Migneault, Denis Girard, Richard Giasson, Antonia Balassy, Louise Blanchard, and Louis Gaboury. Spectroscopic and Photophysical Investigations on the Nature of Localization of Rhodamine-123 and Its Dibromo Derivative in Different Cell Lines. Journal of Fluorescence. Vol. 6, No, 4, 1996

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